Pro-inflammatory role of vasopressin through V1b receptors in hapten- 1 induced experimental colitis in rodents: implication in IBD
نویسندگان
چکیده
1 induced experimental colitis in rodents: implication in IBD 2 3 4 Running head: Vasopressin in experimental colitis 5 6 7 Laurent Ferrier, Claudine Serradeil-Le Gal, Anke M. Schulte, Valentina Vasina, Eric 8 Gaultier, Silke Schroedel, Maria Grazia Ursino, Gilles Chaumaz, Marc Pascal, Fabrizio 9 De Ponti, Lionel Bueno 10 11 12 INRA, UMR 1054 Neuro-Gastroentérologie et Nutrition, Toulouse, France 13 Sanofi-Aventis R&D, Department of Exploratory & Internal Medecine, Toulouse, France 14 Sanofi-Aventis, Frankfurt am Main, Germany 15 University of Bologna, Department of Pharmacology, Bologna, Italy. 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Corresponding author: 36 Dr Lionel BUENO 37 INRA, UMR 1054 Neuro-Gastroentérologie et Nutrition 38 180 chemin de Tournefeuille 39 BP 93173 40 31027 Toulouse Cedex 3 41 Phone : +33 5 61285143 42 Fax : +33 561285397 43 E-mail: [email protected] 44 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (September 23, 2010). doi:10.1152/ajpgi.00022.2010
منابع مشابه
Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD.
Vasopressin and its receptors modulate several gut functions, but their role in intestinal inflammation is unknown. Our aims were to determine 1) the localization of V1b receptors in human and rodent colon, 2) the role of vasopressin and V1b receptors in experimental colitis using two approaches: V1b⁻(/)⁻ mice and a selective V1b receptor antagonist, SSR149415, and 3) the mechanisms involved. V...
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